期刊
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
卷 31, 期 2, 页码 336-346出版社
AMER CHEMICAL SOC
DOI: 10.1021/jasms.9b00098
关键词
ambient ionization; filter cone spray ionization; paper cone spray ionization; portable mass spectrometry; forensics; environmental monitoring; drugs of abuse; abused pharmaceuticals; synthetic cannabinoids; counterfeit pharmaceuticals; agricultural chemicals
资金
- National Institute of Justice, Office of Justice Programs, U.S. Department of Justice [2015-IJ-CX-K011, 2017-R2-CX-0022]
- National Science Foundation MRI Program [CHE 1337497]
The complexity of field-borne sample matrices and the instrumental constraints of portable mass spectrometers (MS) often necessitate that preparative steps are added prior to ambient MS methods when operated on-site, but the corresponding decrease in throughput and experimental simplicity can make field operation impractical. To this end, we report a modified ambient MS method, filter cone spray' ionization (FCSI), specifically designed for simple, yet robust, processing of bulk forensic evidence and environmental samples using a fieldable MS system. This paper-crafted source utilizes low-cost laboratory consumables to produce a conical structure that serves as a disposable, spray-based ionization source. Integrated extraction and filtration capabilities mitigate sample heterogeneity and carryover concerns and expedite sample processing, as characterized through the analysis of a variety of authentic forensic evidence types (e.g., abused pharma tablets, counterfeit/adulterated tablets, crystal-based drugs, synthetic marijuana, toxicological specimens) and contaminated soil samples. The data presented herein suggests that the FCSI-MS design could prove robust to the rigors of field-borne, bulk sample screening, overcoming the inefficiencies of other ambient MS methods for these sample classes. Novel applications of FCSI-MS are also examined, such as the coupling to trace evidence vacuum filtration media.
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