期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 75, 期 8, 页码 931-941出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2019.11.061
关键词
atherosclerosis; endothelial dysfunction; geroscience; microcirculation; senescence
资金
- American Heart Association
- Oklahoma Center for the Advancement of Science and Technology
- Presbyterian Health Foundation
- National Institute on Aging [T32AG052363]
- Cellular and Molecular GeroScience CoBRE [1P20GM125528]
Age-related pathological alterations of the vasculature have a critical rote in morbidity and mortality of older adults. In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macrovascutar and microvascular diseases associated with old age. The rote of cellular senescence in development of vascular aging phenotypes is highlighted, and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. The evidence supporting a role for interorgan communication and circulating progeronic and antigeronic factors in vascular aging is discussed. (C) 2020 by the American College of Cardiology Foundation.
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