期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 1, 页码 327-334出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b10770
关键词
-
资金
- 3M
- Alfred P. Sloan Foundation
- Research Corporation for Science Advancement (RCSA)
- National Institutes of Health (NIH) [R35GM124746]
- UCLA Graduate Division
- NSF Division of Materials Research Grant [1506886]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1506886] Funding Source: National Science Foundation
For decades, chemists have strived to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topology and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据