期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 5, 页码 2549-2561出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b12522
关键词
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资金
- AbbVie Stemcentrx
- Cancer Prevention & Research Institute of Texas (CPRIT)
- Welch Foundation [C-1819]
The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-F and yangpumicin A. This family of natural products provides opportunities in total synthesis, biology, and medicine due to their novel and challenging molecular structures, intriguing biological properties and mechanism of action, and potential in targeted cancer therapies. Herein, the total syntheses of tiancimycins A and B, yangpumicin A, and a number of related anthraquinone-fused enediynes are described. Biological evaluation of the synthesized compounds revealed extremely potent cytotoxicities against a number of cell lines, thus enriching the structure-activity relationships within this class of compounds. The findings of these studies may facilitate future investigations directed toward antibody-drug conjugates for targeted cancer therapies and provide inspiration for further advances in total synthesis and chemical biology.
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