Preparation of manganese-based perovskite nanoparticles using a reverse microemulsion method: biomedical applications

In this study, La0.7Sr0.3Mn0.98Ti0.02O3 (LSMTO) nanoparticles with a perovskite structure and an average particle size of 23.5 nm were synthesized using a reverse microemulsion method. In this method, cetyltrimethylammonium bromide (CTAB) was used as a surfactant, 1-butanol as a co-surfactant, n-hexane as a continuous oil phase, and an aqueous solution containing metal cations or precipitating agent as a dispersed aqueous phase. The aqueous nanodroplets of microemulsions were used for the formation of perovskite precursor. The obtained precursor was then calcined at 700 (a similar to) C for 4 h to convert the precursor to the perovskite phase. In addition, the heating ability of the LSMTO nanoparticles was evaluated under a safe alternating magnetic field used in magnetic hyperthermia therapy. The results showed the fast magneto-temperature response of the prepared sample with sufficient heat loss at the therapeutic temperature range, indicating the LSMTO nanoparticles can be used as a self-regulated heating agent in the magnetic hyperthermia therapy.