Fabrication of Cupric oxide decorated β-cyclodextrin nanocomposite solubilized Nafion as a high performance electrochemical sensor for L-tyrosine detection

In the present work, a novel cupric oxide decorated on beta-cyclodextrin (CuO/beta-CD) nanocomposite was synthesized by sonochemical method. The CuO/beta-CD nanocomposites were characterized by UV-vis, Raman, FT-IR, FE-SEM, mapping analysis, XRD techniques. Fascinatingly, the CuO/beta-CD nanocomposite Nafion (NO solubilized modified glassy carbon electrode (CuO/beta-CD/Nf/GCE) has exhibited a superior electrocatalytic activity towards the L-tyrosine, when compared to the modified beta-CD, CuO, and bare GCE electrodes. Besides, the electrochemical sensing performance was revealed as an excellent amperometric i-t current response for the L-tyrosine determination with a wide linear range from 0.01 to 100 mu M, high sensitivity 442 mu A mu(M-1CM2) and low detection limit (LOD) 0.0082 mu M. Furthermore, it manifested a good selectivity, repeatability, stability, and reproducibility. In addition, the CuO/beta-CD/Nf modified GCE electrode shows good sensibleness for the L-tyrosine detection of blood serum, food samples, and urine samples.