期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 161, 期 2, 页码 245-247出版社
SPRINGER
DOI: 10.1007/s10517-016-3387-1
关键词
ischemic stroke; coenzyme Q(10) (ubiquinone); antioxidant; neuroprotection
The neuroprotective effect of ubiquinone (coenzyme Q(10))was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q(10) (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.
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