期刊
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 11, 期 4, 页码 1357-1363出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.9b03891
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资金
- National Natural Science Foundation of China [NSFC 21573019, 21872010]
Large doses of anticancer drugs entering cancer cell nuclei are found to be effective at killing cancer cells and increasing chemotherapeutic effectiveness. Here we report red-emissive carbon quantum dots, which can enter into the nuclei of not only cancer cells but also cancer stem cells. After doxorubicin was loaded at the concentration of 30 mu g/mL on the surfaces of carbon quantum dots, the average cell viability of HeLa cells was decreased to only 21%, while it was decreased to 50% for free doxorubicin. The doxorubicin-loaded carbon quantum dots also exhibited a good therapeutic effect by eliminating cancer stem cells. This work provides a potential strategy for developing carbon quantum-dot-based anticancer drug carriers for effective eradication of cancers.
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