期刊
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 11, 期 4, 页码 1228-1238出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.9b03769
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资金
- National Natural Science Foundation of China [31671014, 51672262, 51761145046]
- Ministry of Education of China (Fundamental Research Funds for the Central Universities) [WK3450000002, WK2060140023]
Sonodynamic therapy eliminates cancer cells with reactive oxygen species (ROS) triggered by ultrasound whose energy is spatiotemporally controllable, is safe to human tissues and organs, and penetrates deeply through tissues. Its application, however, is hindered by the scarcity of sonodynamic sensitizers. We herein demonstrate piezoelectric materials as a new source of sonodynamic sensitizers, using few-layer black phosphorus (BP) nanosheet as a model. BP nanosheet exhibited ultrasound-excited cytotoxicity to cancer cells via ROS generation, thereby suppressing tumor growth and metastasis without causing off-target toxicity in tumor-bearing mouse models. The ultrasonic wave introduces mechanical strain to the BP nanosheet, leading to piezoelectric polarization which shifts the conduction band of BP more negative than O-2/center dot O-2(-) while its valence band more positive than H2O/center dot OH, thereby accelerating the ROS production. This work identifies a new mechanism for discovering sonodynamic sensitizers and suggests BP nanosheet as an excellent sensitizer for tumor sonodynamic therapy.
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