期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 160, 期 4, 页码 560-564出版社
SPRINGER
DOI: 10.1007/s10517-016-3218-4
关键词
endometrium; multipotent mesenchymal stromal cells; immunophenotype; viability
资金
- Russian Science Foundation [14-25-00179]
Cell cultures isolated from human endometrium by enzyme digestion consisted of highly viable fibroblast-like mesenchymal cells expressing CD90, CD73, and CD105. During passage 1, the cultures contained a small fraction of cytokeratin-7(+) epithelial cells that disappeared by passage 2. The cultures from the endometrium could be induced to adipogenic, osteogenic and chondrogenic differentiation in vitro. These findings suggest that human endometrium is a convenient source of biomaterial for minimally invasive isolation of cultures that exhibit typical morphology and immunophenotypic profile of resident multipotent mesenchymal stromal cells retain high viability in vitro.
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