期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 160, 期 5, 页码 687-690出版社
SPRINGER
DOI: 10.1007/s10517-016-3250-4
关键词
schizophrenia; tardive dyskinesia; hyperprolactinemia; gene polymorphism; cytochromes
资金
- Russian Science Foundation [14-35-00023]
- Russian Science Foundation [14-35-00023] Funding Source: Russian Science Foundation
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G > A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time.
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