期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 160, 期 6, 页码 767-770出版社
SPRINGER
DOI: 10.1007/s10517-016-3305-6
关键词
cellulose sulfate; anticoagulant; aIIa activity; aXa activity
资金
- Federal Targeted Program for Research and Development in Priority Areas of Development of the Russian Scientific and Technological Complex [RFME-FI60714X0031]
- Presidium of Russian Academy of Sciences Fundamental Sciences for Medicine
Experiments on rabbits showed that increasing the dose of intravenously administered cellulose sulfate from wheat straw (dynamic viscosity 3.4 cP, sulfur content 14.1%) increased plasma clotting time in some coagulation tests and plasma anticoagulant activity. When cellulose sulfate was administered in the dose of 1 mg/kg, plasma clotting time in the presence of the anticoagulant (5 min after administration) was similar to 3-fold higher than after saline administration.
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