期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 180, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jpba.2019.113067
关键词
Eph-ephrin system; UniPR1331; High performance liquid chromatography (HPLC); High-resolution mass spectrometry (HR-MS); Drug-gut microbiota interactions; Faecal fermentation assay
资金
- Centro Interdipartimentale Misure (CIM) G. Casnati of the University of Parma
The interest on the role of gut microbiota in the biotransformation of drugs and xenobiotics has grown over the last decades and a deeper understanding of the mutual interactions is expected to help future improvements in the fields of drug development, toxicological risk assessment and precision medicine. In this paper, a microbiome drug metabolism case is presented, involving a lipophilic small molecule,N-(3 beta-hydroxy-Delta(5)-cholen-24-oyl)-L-tryptophan, UniPR1331, active as antagonist of the Eph ephrin system and effective in vivo in a murine orthotopic model of glioblastoma multiforme (GBM). Following the administration of a single 30 mg/l
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