期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 160, 期 3, 页码 364-367出版社
SPRINGER
DOI: 10.1007/s10517-016-3172-1
关键词
oxidative stress; redox regulation; breast adenocarcinoma; apoptosis; tumor progress
资金
- Russian Humanitarian Research Foundation [15-36-01289]
MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.
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