期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 160, 期 6, 页码 831-834出版社
SPRINGER
DOI: 10.1007/s10517-016-3321-6
关键词
HepaRG; spheroid; silver; nanoparticles; model
资金
- Federal Target Program Research and Development in the Priority Areas of Development of the Russian Scientific and Technological Complex [14.513.11.0125]
We studied the effects of silver nanoparticles (10 nm) on HepaRG cell spheroids simulating liver tissue. The mathematical model was proposed that describes nanoparticle diffusion in a spheroid consisting of 5000 cells depending on the external nanoparticle concentration. It was demonstrated that cells in the 3D model were less sensitive to the toxic effects of nanoparticles in comparison with 2D cultures. Impaired integrity of the cell membrane did not deteriorate cell viability (according to MTT test).
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