期刊
JOURNAL OF PERIODONTOLOGY
卷 91, 期 10, 页码 1318-1327出版社
WILEY
DOI: 10.1002/JPER.19-0613
关键词
aspirin; diabetes; immunomodulation; inflammation; omega-3 fatty acids; periodontitis
资金
- SAo Paulo Research Foundation (Fapesp) [2016/02234-7, 2017/21136-9]
- National Institute of Dental and Craniofacial Research (NIH) (USPHS) [DE025020]
Background Supplementation with omega-3 polyunsaturated fatty acids (omega-3 PUFA) and low-dose aspirin (ASA) have been proposed as a host modulation regimen to control chronic inflammatory diseases. The aim of this study was to investigate the clinical and immunological impact of orally administered omega-3 PUFA and ASA as adjuncts to periodontal debridement for the treatment of periodontitis in patients type 2 diabetes. Methods Seventy-five patients (n = 25/group) were randomly assigned to receive placebo and periodontal debridement (CG), omega-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months)afterperiodontal debridement (test group [TG]1), or omega-3 PUFA + ASA (3 g of fish oil/d + 100 mg ASA/d for 2 months)beforeperiodontal debridement (TG2). Periodontal parameters and GCF were collected at baseline (t0), 3 months after periodontal debridement and omega-3 PUFA + ASA or placebo for TG1 and CG (t1), after omega-3 PUFA + ASA (before periodontal debridement) for TG2 (t1), and 6 months after periodontal debridement (all groups) (t2). GCF was analyzed for cytokine levels by multiplex ELISA. Results Ten patients (40%) in TG1 and nine patients (36%) in TG2 achieved the clinical endpoint for treatment (less than or equal to four sites with probing depth >= 5 mm), as opposed to four (16%) in CG. There was clinical attachment gain in moderate and deep pockets for TG1. IFN-gamma and interleukin (IL)-8 levels decreased over time for both test groups. IL-6 levels were lower for TG1. HbA1c levels reduced for TG1. Conclusion Adjunctive omega-3 and ASA after periodontal debridement provides clinical and immunological benefits to the treatment of periodontitis in patients with type 2 diabetes.
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