期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 85, 期 6, 页码 4482-4499出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c00207
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资金
- ERDF [1.1.1.5/17/A/004]
A new method for cobalt-catalyzed C(sp(2))-H functionalization of phenylglycinol derivatives with terminal and internal alkynes directed by picolinamide auxiliary has been developed. This method offers an efficient and highly regioselective route for the synthesis of 1-hydroxymethyltetrahydroisoquinolines. The reaction employs commercially available Co(II) catalyst in the presence of Mn(III) cooxidant and oxygen as a terminal oxidant and proceeds with full preservation of original stereochemistry.
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