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Daniel Erskine et al.
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Raquel Pinho et al.
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Abby L. Olsen et al.
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Arwa A. Abugable et al.
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Allison J. Schaser et al.
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Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease
Petar Podlesniy et al.
EBIOMEDICINE (2019)
POLG-related disorders and their neurological manifestations
Shamima Rahman et al.
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Mike A. Nalls et al.
LANCET NEUROLOGY (2019)
RAD52 is required for RNA-templated recombination repair in post-mitotic neurons
Starr Welty et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity
Alexia F. Kalogeropulou et al.
BIOCHEMICAL JOURNAL (2018)
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease
Emily M. Rocha et al.
NEUROBIOLOGY OF DISEASE (2018)
Parkin and PINK1 mitigate STING-induced inflammation
Danielle A. Sliter et al.
NATURE (2018)
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease
Chiara Milanese et al.
CELL DEATH & DISEASE (2018)
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases
Nathan A. Berger et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin
Timothy L. Scott et al.
MOLECULAR CARCINOGENESIS (2017)
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage
Isabel Paiva et al.
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LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease
Evan H. Howlett et al.
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Velmarini Vasquez et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
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Diana Chang et al.
NATURE GENETICS (2017)
Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk
Laurie H. Sanders et al.
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Simplified qPCR method for detecting excessive mtDNA damage induced by exogenous factors
Artem P. Gureev et al.
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VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2
Seung Pil Yun et al.
CELL DEATH & DISEASE (2017)
Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
Heather M. Wilkins et al.
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Parkinson disease
Werner Poewe et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models
Valentin Evsyukov et al.
DISEASE MODELS & MECHANISMS (2017)
Damage to dopaminergic neurons is mediated by proliferating cell nuclear antigen through the p53 pathway under conditions of oxidative stress in a cell model of Parkinson's disease
Da-Wei Li et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)
FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration
Changsun Yu et al.
CELL DEATH AND DIFFERENTIATION (2016)
Genetic modification of H2AX renders mesenchymal stromal cell-derived dopamine neurons more resistant to DNA damage and subsequent apoptosis
Peizhou Jiang et al.
CYTOTHERAPY (2016)
Mitochondrial DNA damage induced autophagy, cell death, and disease
Bennett Van Houten et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2016)
Mitochondrial dysfunction in Parkinson's disease
Anindita Bose et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Mitochondrial DNA homeostasis is essential for nigrostriatal integrity
Charalampos Tzoulis et al.
MITOCHONDRION (2016)
Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62
Yanan Wang et al.
MOLECULAR CELL (2016)
Mitochondrial DNA exhibits resistance to induced point and deletion mutations
William J. Valente et al.
NUCLEIC ACIDS RESEARCH (2016)
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
Christian Dolle et al.
NATURE COMMUNICATIONS (2016)
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Sara Sepe et al.
CELL REPORTS (2016)
Mechanisms of ATM Activation
Tanya T. Paull
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84 (2015)
ATM and ATR signaling at a glance
Poorwa Awasthi et al.
JOURNAL OF CELL SCIENCE (2015)
DNA Damage, DNA Repair, Aging, and Neurodegeneration
Scott Maynard et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)
Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?
Amy Reeve et al.
AGEING RESEARCH REVIEWS (2014)
Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3
Carole Beck et al.
EXPERIMENTAL CELL RESEARCH (2014)
Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily
Klodjan Stafa et al.
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Understanding nucleotide excision repair and its roles in cancer and ageing
Jurgen A. Marteijn et al.
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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Laurie H. Sanders et al.
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Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease
Laurie H. Sanders et al.
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The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle
Kai-Li Ma et al.
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Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans
Claudia P. Gonzalez-Hunt et al.
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Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations
Charalampos Tzoulis et al.
BRAIN (2013)
Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress
Ming Zhou et al.
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ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform
Luc Friboulet et al.
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Tommaso Cornetta et al.
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Nucleotide excision repair in chronic neurodegenerative diseases
Sara Sepe et al.
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Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
Laurie H. Sanders et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
The Maintenance of Mitochondrial DNA Integrity-Critical Analysis and Update
Mikhail Alexeyev et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
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Coro Paisan-Ruiz et al.
JOURNAL OF PARKINSONS DISEASE (2013)
Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease
Michael T. Lin et al.
ANNALS OF NEUROLOGY (2012)
Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson's disease
Almas Siddiqui et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
DNA Repair Genes in Parkinson's Disease
Mehmet Gencer et al.
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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
Xinglong Wang et al.
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Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
Jingwen Niu et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP
Fernando Cardozo-Pelaez et al.
NEUROCHEMISTRY INTERNATIONAL (2012)
Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death
Jaume Folch et al.
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Single-Cell Redox Imaging Demonstrates a Distinctive Response of Dopaminergic Neurons to Oxidative Insults
Maxx P. Horowitz et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
6-OHDA generated ROS induces DNA damage and p53-and PUMA-dependent cell death
Alison I. Bernstein et al.
MOLECULAR NEURODEGENERATION (2011)
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease
Philipp Koch et al.
NATURE (2011)
ATR: a master conductor of cellular responses to DNA replication stress
Rachel Litman Flynn et al.
TRENDS IN BIOCHEMICAL SCIENCES (2011)
Overview of Base Excision Repair Biochemistry
Yun-Jeong Kim et al.
Current Molecular Pharmacology (2011)
Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
Antoni Camins et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Pathological implications of cell cycle re-entry in Alzheimer disease
David J. Bonda et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2010)
The MitoPark Mouse - An animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons
Mats Ekstrand et al.
PARKINSONISM & RELATED DISORDERS (2009)
Comparison of nonhomologous end joining and homologous recombination in human cells
Zhiyong Mao et al.
DNA REPAIR (2008)
Single-strand break repair and genetic disease
Keith W. Caldecott
NATURE REVIEWS GENETICS (2008)
Sequential and concerted gene expression changes in a chronic in vitro model of parkinsonism
J. G. Greene et al.
NEUROSCIENCE (2008)
Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/P53/E2F-1 path in cerebellar granule neurons
Daniel Alvira et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons
D. Alvira et al.
NEUROSCIENCE (2007)
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Guenter U. Hoeglinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mitochondria and neuronal activity
Oliver Kann et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
DNA repair in neurons: So if they don't divide what's to repair?
Melissa L. Fishel et al.
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Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease
Takeo Arai et al.
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Muralidhar L. Hegde et al.
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Paula M. Keeney et al.
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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
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Y Kraytsberg et al.
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Rotenone model of Parkinson disease - Multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication
A Panov et al.
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J Fukae et al.
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Expression patterns of retinoblastoma protein in Parkinson disease
KL Jordan-Sciutto et al.
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DNA damage in brain mitochondria caused by aging and MPTP treatment
BS Mandavilli et al.
BRAIN RESEARCH (2000)
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H Shimura et al.
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