期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 337, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2019.577071
关键词
Autism spectrum disorders (ASD); Th17 lymphocytes; Treg lymphocytes; Cytokines
We aimed in this study to investigate a possible involvement of Th17/Treg cells imbalance in autism spectrum disorders (ASD). Using flowcytometry to determine circulating Th17 and Treg cells percentages, RT- PCR and ELISA for cytokine expression, we demonstrated that Th17/Treg balance in ASD children was significantly skewed toward a Th17 response compared to their control. Th17 cells and the ratio of Th17/Treg cells had a significantly positive correlation with disease severity whereas Treg cells had a negative correlation. The imbalance of Th17, Treg cells and their related cytokines may play a vital role in the progression of the disease.
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