期刊
JOURNAL OF NEPHROLOGY
卷 33, 期 2, 页码 239-249出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s40620-019-00685-0
关键词
Vitamin K; Bone disease; Vascular calcifications; Cancer; Chronic kidney disease
Vitamin K is a cofactor for the function of the enzyme gamma-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.
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