期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 2, 页码 461-467出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b01061
关键词
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资金
- Usona Institute
- National Institute on Drug Abuse [NIDA RO1 DA041336]
- Veteran's Affairs VISN 22 MIRECC
- UCSD T32 Fellowship in Biological Psychiatry Neuroscience [NIMH T32 MH018399]
A general synthetic method was developed to access known tryptamine natural products present in psilocybin-producing mushrooms. In vitro and in vivo experiments were then conducted to inform speculations on the psychoactive properties, or lack thereof, of the natural products. In animal models, psychedelic activity by baeocystin alone was not evident using the mouse head twitch response assay, despite its putative dephosphorylated metabolite, norpsilocin, possessing potent agonist activity at the 5-HT2A receptor.
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