期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 1, 页码 36-44出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00515
关键词
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资金
- National Key Research and Development Program of China [2018YFA0507204]
- National Natural Science Foundation of China [U1703107, U1801288]
- Natural Science Foundation of Tianjin [19JCYBJC28100]
- Hundred Young Academic Leaders Program of Nankai University
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2019-B01]
- Key Laboratory of Xinjiang Uygur Autonomous Region [2015KL030, 2017D04019]
A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G(0)/G(1) stage.
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