期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 12, 页码 3440-3449出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00834
关键词
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资金
- National Natural Science Foundation of China [41906106, 31272087]
- GDAS' Project of Science and Technology Development [2019GDASYL-0103007]
- Science and Technology Program of Guangzhou, China [201607020018]
- Team Project of the Natural Science Foundation of Guangdong Province [2016A030312014]
- Guangdong MEDP fund [GDOE[2019]A35]
- Guangdong Natural Science and Technology Project [2017A050506022]
Fiscpropionates A-F (1-6), six new polypropionate derivatives featuring an unusual long hydrophobic chain, were isolated from the deep -sea-derived fungus Aspergillus fischeri FS452. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were determined by J-HMBC analysis, electronic circular dichroism (ECD) calculations, and the modified Mosher's method. This is the first discovery of polypropionates from marine -derived fungi, and compounds 4 and 5 represent the first examples of polypropionate derivatives containing a 3-hydroxypiperidin-2-one as part of an imide linkage. In addition, compounds 1-4 exhibited significant inhibitory activities against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the ICso values of 5.1, 12, 4.0, and 11 mu M, respectively. Enzyme kinetic experiments suggested that they all acted through a noncompetitive mechanism. A preliminary structure activity relationship is discussed.
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