相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Effects of Selonsertib in Patients with Diabetic Kidney Disease
Glenn M. Chertow et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1-and ABCG2-overexpressing cancer cells
Ning Ji et al.
CANCER LETTERS (2019)
Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation
Alexandre Kanashiro et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2018)
The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial
Rohit Loomba et al.
HEPATOLOGY (2018)
Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer's Disease and Brain Aging
Yu Hasegawa et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
Riluzole does not improve lifespan or motor function in three ALS mouse models
Marion C. Hogg et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2018)
ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension
Grant R. Budas et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)
Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis
Gyrid Nygaard et al.
BIOCHEMICAL PHARMACOLOGY (2018)
Redox-Inactive Peptide Disrupting Trx1-Ask1 Interacion for Selective Activation of Stress Signaling
Dilini N. Kekulandara et al.
BIOCHEMISTRY (2018)
Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease
Mathew S. Eapen et al.
CLINICAL SCIENCE (2018)
ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis
Liv A. Amos et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)
Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib
Zobair M. Younossi et al.
LIVER INTERNATIONAL (2018)
ASK1 contributes to fibrosis and dysfunction in mode of kidney disease
John T. Liles et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease
Furong Yan et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2018)
Novel ASK1 Inhibitor AGI-1067 Attenuates AGE-Induced Fibrotic Response by Suppressing the MKKs/p38 MAPK Pathway in Human Coronary Arterial Smooth Muscle Cells
Zhongwei Liu et al.
INTERNATIONAL HEART JOURNAL (2018)
Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation
Meghna U. Naik et al.
BLOOD (2017)
Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces liver fibrosis and apoptosis in a NLRP3 mutant model of NASH
S. Schuster et al.
JOURNAL OF HEPATOLOGY (2017)
Cysteines as Redox Molecular Switches and Targets of Disease
Annamaria Fra et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets
Miki Kamiyama et al.
CELL DEATH AND DIFFERENTIATION (2017)
The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis
Takao Fujisawa et al.
HUMAN MOLECULAR GENETICS (2016)
Stress-Induced Activation of Apoptosis Signal-Regulating Kinase 1 Promotes Osteoarthritis
Qian-Shi Zhang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2016)
Cysteine residues mediate high-affinity binding of thioredoxin to ASK1
Salome Kylarova et al.
FEBS JOURNAL (2016)
Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes
Zobair M. Younossi et al.
HEPATOLOGY (2016)
Protective effect of apoptosis signal-regulating kinase1 inhibitor against mice liver injury
Ping He et al.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2016)
ASK1 signalling regulates brown and beige adipocyte function
Kazuki Hattori et al.
NATURE COMMUNICATIONS (2016)
Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma
Cai-Feng Jiang et al.
ONCOTARGET (2016)
K/BxN Serum-Transfer Arthritis as a Model for Human inflammatory Arthritis
Anne D. Christensen et al.
FRONTIERS IN IMMUNOLOGY (2016)
p38 gamma and p38 delta Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
Alejandra Escos et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1
Hunsung Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one
Sergiy A. Starosyla et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice
Greg H. Tesch et al.
DIABETES (2015)
Cysteine Oxidation Targets Peroxiredoxins 1 and 2 for Exosomal Release through a Novel Mechanism of Redox-Dependent Secretion
Lisa Mullen et al.
MOLECULAR MEDICINE (2015)
Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury
Yuchao Xie et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)
Oscillation of p38 activity controls efficient pro-inflammatory gene expression
Taichiro Tomida et al.
NATURE COMMUNICATIONS (2015)
ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice
Kensuke Toyama et al.
SCIENTIFIC REPORTS (2015)
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Carmen G. Tag et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)
Depletion of Apoptosis Signal-Regulating Kinase 1 Prevents Bile Duct Ligation-Induced Necroinflammation and Subsequent Peribiliary Fibrosis
Hirotsugu Noguchi et al.
AMERICAN JOURNAL OF PATHOLOGY (2014)
Apoptosis Signal- Regulating Kinase 1 Is a Novel Target Molecule for Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion
Kensuke Toyama et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
Oxidative stress as a crucial factor in liver diseases
Halina Cichoz-Lach et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2014)
Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival
G. J. Eaton et al.
CELL DEATH & DISEASE (2014)
ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney
Frank Y. Ma et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)
Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
Weihua Zhao et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)
Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
William A. Eimer et al.
MOLECULAR NEURODEGENERATION (2013)
Deletion of Apoptosis Signal-Regulating Kinase-1 Prevents Ventilator-Induced Lung Injury in Mice
Patrudu S. Makena et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
Yoshito Terao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer
Yoku Hayakawa et al.
CANCER SCIENCE (2012)
Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells
Reagan M. Jarvis et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
An Apoptosis Signal-regulating Kinase 1 Inhibitor Reduces Cardiomyocyte Apoptosis and Infarct Size in a Rat Ischemia-reperfusion Model
Paul Z. Gerczuk et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2012)
Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts
Hsi-Kai Tsou et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
Mitchell R. McGill et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal A beta aggregation in the 5XFAD mouse model of Alzheimer's disease
Sadim Jawhar et al.
NEUROBIOLOGY OF AGING (2012)
P38 MAPK: AN IMPORTANT PATHWAY IN THE PATHOBIOLOGY OF PULMONARY HYPERTENSION AND PULMONARY VASCULAR REMODELLING
A. C. Church et al.
THORAX (2012)
Evaluation of JNK Blockade as an Early Intervention Treatment for Type 1 Diabetic Nephropathy in Hypertensive Rats
Andy K. H. Lim et al.
AMERICAN JOURNAL OF NEPHROLOGY (2011)
Apoptosis Signal-Regulating Kinase 1 Inhibits Hepatocarcinogenesis by Controlling the Tumor-Suppressing Function of Stress-Activated Mitogen-Activated Protein Kinase
Hayato Nakagawa et al.
HEPATOLOGY (2011)
Peroxiredoxin-2 Protects against 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration via Attenuation of the Apoptosis Signal-Regulating Kinase (ASK1) Signaling Cascade
Xiaoming Hu et al.
JOURNAL OF NEUROSCIENCE (2011)
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis
Jaemin Lee et al.
NATURE MEDICINE (2011)
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer
Yoku Hayakawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway
Xiaoli Guo et al.
EMBO MOLECULAR MEDICINE (2010)
Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis
Stephen J. Mnich et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2010)
Silencing Glycogen Synthase Kinase-3β Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1
Mie Shinohara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
Matthew B. Greenblatt et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Evaluation of the Efficacy and Safety of Pamapimod, a p38 MAP Kinase Inhibitor, in a Double-Blind, Methotrexate-Controlled Study of Patients With Active Rheumatoid Arthritis
Stanley B. Cohen et al.
ARTHRITIS AND RHEUMATISM (2009)
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
Rocio Sancho et al.
EMBO JOURNAL (2009)
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes
Adeel Ijaz et al.
KIDNEY INTERNATIONAL (2009)
REDOX Reaction at ASK1-Cys250 Is Essential for Activation of JNK and Induction of Apoptosis
Philippe J. Nadeau et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz
Julie Hull-Thompson et al.
PLOS GENETICS (2009)
Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
Takahiro Nakayama et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)
Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
Hidefumi Ito et al.
EXPERIMENTAL NEUROLOGY (2008)
A novel function of peroxiredoxin 1 (Prx-1) in apoptosis signal-regulating kinase 1 (ASK1)-mediated signaling pathway
So Yong Kim et al.
FEBS LETTERS (2008)
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-jun N-terminal kinase activation
Hayato Nakagawa et al.
GASTROENTEROLOGY (2008)
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
Hideki Nishitoh et al.
GENES & DEVELOPMENT (2008)
Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition
Eiichiro Yamamoto et al.
HYPERTENSION (2008)
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury
Naoko Hanawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis
Kimberly K. Brown et al.
JOURNAL OF INFLAMMATION-LONDON (2008)
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
P. Hemachandra Reddy et al.
TRENDS IN MOLECULAR MEDICINE (2008)
The mechanisms of alloxan- and streptozotocin-induced diabetes
S. Lenzen
DIABETOLOGIA (2008)
Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury
Yoshio Terada et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
Gary L. Johnson et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification
Kozo Morita et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
Chang Tong et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity
Adrien A. Eshraghi et al.
HEARING RESEARCH (2007)
Collagen-induced arthritis
David D. Brand et al.
NATURE PROTOCOLS (2007)
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
Gurol Tuncman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Chemical genetic analysis of the time course of signal transduction by JNK
JJ Ventura et al.
MOLECULAR CELL (2006)
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure
TJ Davern et al.
GASTROENTEROLOGY (2006)
The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIPL turnover
LF Chang et al.
CELL (2006)
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS
P Veglianese et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2006)
The isoform-specific functions of the c-Jun N-terminal kinases (JNKs): differences revealed by gene targeting
Marie A. Bogoyevitch
BIOESSAYS (2006)
Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study
AM Larson et al.
HEPATOLOGY (2005)
NF-κB-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
K Aya et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice
SS Holasek et al.
BRAIN RESEARCH (2005)
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation
H Kadowaki et al.
CELL DEATH AND DIFFERENTIATION (2005)
Activation of programmed cell death markers in ventral horn motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in a transgenic mouse model
TM Wengenack et al.
BRAIN RESEARCH (2004)
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling
O Yamaguchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia
Y Izumi et al.
CIRCULATION (2003)
Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II - Induced cardiac hypertrophy and remodeling
Y Izumiya et al.
CIRCULATION RESEARCH (2003)
Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1
JJ Song et al.
BIOCHEMICAL JOURNAL (2003)
JunD mediates survival signaling by the JNK signal transduction pathway
JA Lamb et al.
MOLECULAR CELL (2003)
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
G Ostapowicz et al.
ANNALS OF INTERNAL MEDICINE (2002)
Rescue of auditory hair cells from ototoxicity by CEP-11004, an inhibitor of the JNK signaling pathway
D Bodmer et al.
LARYNGO-RHINO-OTOLOGIE (2002)
Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner
YM Liu et al.
CIRCULATION RESEARCH (2002)
Mode of cell death after acetaminophen overdose in mice: Apoptosis or oncotic necrosis?
JS Gujral et al.
TOXICOLOGICAL SCIENCES (2002)
Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer
K Tobiume et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2002)
NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun
HL Liu et al.
HEPATOLOGY (2002)
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
K Tobiume et al.
EMBO REPORTS (2001)
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
JS Mudgett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)