期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 432, 期 8, 页码 2560-2588出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2020.01.017
关键词
autophagy; cellular stress; nervous system; neuron; neurodegenerative disease
资金
- Nanyang Technological University, Singapore
- Technological Research Council of Turkey (TUBITAK 1003 Project) [216S489]
- Sabanci University
- EMBO Strategical Development and Installation Grant (EMBO-SDIG)
- Turkish Academy of Sciences (TUBA) GEBIP Award
- TGC Sedat Simavi Health Sciences Award
- Elginkan Foundation Technology Award
- IKU
Cells of an organism face with various types of insults during their lifetime. Exposure to toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases, neurodegenerative diseases are among the conditions that trigger cellular stress responses. In this context, autophagy is one of the mechanisms that supports cell survival under stressful conditions. Autophagic vesicle engulfs the cargo and transports it to lysosome for degradation and turnover. As such, autophagy eliminates abnormal proteins, clears damaged organelles, limits oxidative stress and helps to improve metabolic balance. Nervous system cells and particularly postmitotic neurons are highly sensitive to a spectrum of insults, and autophagy emerges as one of the key stress response mechanism, ensuring health and survival of these vulnerable cell types. In this review, we will overview mechanisms through which cells cope with stress, and how these stress responses regulate autophagy, with a special focus on the nervous system. (C) 2020 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据