期刊
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
卷 54, 期 3, 页码 466-473出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.jmii.2020.01.009
关键词
Asthma; Atopic indices; Children; Oxidative stress; Rhinitis
资金
- Chang Gung Medical Foundation, Taiwan [CMRPG3E1191-5]
Oxidative stress is correlated with allergic indices and may play a role in modulating allergic responses contributing to the development of atopic diseases.
Background: The association between oxidative stress and atopic diseases is uncertain. Several risk factors for atopic diseases have been identified, however, a comprehensive investigation of the relationship between oxidative stress markers and atopic indices related to atopic diseases is currently lacking. Methods: We investigated 132 children who completed a 7-years follow-up in a birth cohort. Oxidative stress markers including plasma glutathione peroxidase (GPx), myeloperoxidase (MPO), total anti-oxidant capacity (TAC), and urine 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels were measured. Allergen-specific IgE levels, FeNO levels, and pulmonary function tests were also obtained. Results: The activity of GPx and levels of MPO were inversely correlated to food (shrimp and crab) and house dust mite sensitization respectively. The 8-OHdG levels were strongly negatively correlated with FeNO levels (p < 0.01). A significant positive correlation was found between TAC levels and pre-and post-bronchodilator FVC % and FEV1% predicted (p < 0.05). All oxidative stress markers were not associated with the risk of atopic diseases. However, GPx-related crab sensitization and 8-OHdG related FeNO levels were significantly associated with increased risk of allergic rhinitis, while MPO-related mite sensitization and TAC-related pulmonary function parameters were strongly associated with risk of asthma (p < 0.01). Conclusion: Oxidative stress is strongly correlated with allergic indices, potentially playing a role in the modulation of allergic responses contributing to atopic diseases. Copyright (C) 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
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