期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 63, 期 6, 页码 3359-3369出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b02042
关键词
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资金
- HOMING Programme, a Grant Project of the Foundation for Polish Science - European Union [2016-3/24]
- L'Oreal Poland
- Polish Ministry of Science and Higher Education
Cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKs) kill compromised cells to defend against tumor and viral infections. Both effector cell types use multiple strategies to induce target cell death including Fas/CD95 activation and the release of perforin and a group of lymphocyte granule serine proteases called granzymes. Granzymes have relatively broad and overlapping substrate specificities and may hydrolyze a wide range of peptidic epitopes; it is therefore challenging to identify their natural and synthetic substrates and to distinguish their localization and functions. Here, we present a specific and potent substrate, an inhibitor, and an activity-based probe of Granzyme A (GrA) that can be used to follow functional GrA in cells.
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