期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 63, 期 5, 页码 2028-2034出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b01546
关键词
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资金
- EPSRC [EP/L016559/1]
- MRC (OPTIMA CDT Studentship) [EP/L016559/1]
- Cancer Research UK [C157/A25140, C157/A15703]
- UK Regenerative Medicine Platform Niche Hub, MRC grant [MR/K026666/1]
- MRC [MR/K026666/1] Funding Source: UKRI
Stimulated Raman scattering (SRS) microscopy represents a powerful method for imaging label-free drug distribution with high resolution. SRS was applied to image label-free ponatinib with high sensitivity and specificity in live human chronic myeloid leukemia (CML) cell lines. This was achieved at biologically relevant, nanomolar concentrations, allowing determination of ponatinib uptake and sequestration into lysosomes during the development of acquired drug resistance and an improved understanding of target engagement.
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