期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 63, 期 1, 页码 433-439出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b01465
关键词
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资金
- National Institute on Drug Abuse [DA47855, DA48353]
- State of Florida
Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), had higher affinity at opioid receptors than at adrenergic receptors while the vice versa was observed for corynantheidine. The observed polypharmacology of kratom alkaloids may support its utilization to treat opioid use disorder and withdrawal.
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