期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 63, 期 8, 页码 3785-3816出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b01039
关键词
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资金
- National Natural Science Foundation of China [81872737, 81930100, 81773639]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2017ZX09302003, 2018ZX09711002]
- Double First Class Innovation Team of China Pharmaceutical University [CPU2018GY02]
- Program for Outstanding Scientific and Technological Innovation Team of Jiangsu Higher Education
- Open Project of State Key Laboratory of Natural Medicines [SKLNMZZCX201803]
- Fundamental Research Funds for the Central Universities of China Pharmaceutical University [2632018ZD15]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of type I interferons aanugsei and proinflammatory cytokines and is triggered by cytosolic DNA of pathogen and host origins. Given that STING is a mediator in the immune system, pharmacological modulation of STING has shown viable therapeutic effects for pathogen infection, cancer, and inflammatory diseases. In the past decade, the substantial development in this field has encouraged the discovery of STING modulators. Here, we will summarize the current understanding of STING structure, survey the status quo of STING modulators, compare established bioassay methods, review the chemical structures and bioactivities of agonists and inhibitors, and propose suggestions and insights for the future exploitation of STING modulators.
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