期刊
JOURNAL OF MEDICAL VIROLOGY
卷 92, 期 4, 页码 424-432出版社
WILEY
DOI: 10.1002/jmv.25685
关键词
chemokine; coronavirus; cytokines; inflammation; interferon
类别
资金
- National Natural Science Foundation of China [81730061, 81902066, 81471942]
Coronaviruses (CoVs) are by far the largest group of known positive-sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health. The immune response is essential to control and eliminate CoV infections, however, maladjusted immune responses may result in immunopathology and impaired pulmonary gas exchange. Gaining a deeper understanding of the interaction between Coronaviruses and the innate immune systems of the hosts may shed light on the development and persistence of inflammation in the lungs and hopefully can reduce the risk of lung inflammation caused by CoVs. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment.
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