期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 201, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2019.110816
关键词
Benzo-N-heterocycles; Transition metal complex; Cytotoxicity; Apoptosis
资金
- National Natural Science Foundation of China [81402309]
- Training Scheme for Young Key Teachers of Colleges and Universities of Henan [2016GGJS-139]
- Scientific Research Promotion Project of Henan University of Urban Construction [2016QY017]
- Funding Program for Academic Technology Leaders of Henan University of Urban Construction [YCJXSJSDTR201705]
Three novel transition metal complexes, Cu(p-2-bmq)Cl-2 (1), Zn(p-2-bmq)CL2 (2) and [Co(p-2-bmq)Cl-2](2) (3) (where p-2-bmq = 2-((1-(pyridin-2-yl)-1H-benzoimidazol-2-yl)methyl) quinolone, have been synthesized. The complexes were detected for their cytotoxicity in vitro against four human esophageal cancer cell lines (SMMC7721, BGC823, HCT116 and HT29) by MTT assay. The results showed that they all have anti-tumor cell proliferation activity. E specially, complex 1 exhibited significant cytotoxicity with IC50 value of 15.89 mu M against SMMC7721 cells for 72 h. The morphological changes of nuclei by fluorescence staining methods proved that complex 1 could induce intracellular DNA damage. The flow cytometry analysis revealed that the treatment of SMMC7721 cells with complex 1 induced intracellular ROS increased, mitochondrial potential collapse, G2/M-phase arrest, and even apoptosis. These studies should highly valuable for the development of transition metal-based compounds to the potential anticancer medicinal applications.
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