Antibacterial wound dressing electrospun nanofibrous material from polyvinyl alcohol, honey and Curcumin longa extract

In the recent years, the medical sector is getting increasingly interested in the wound dressing materials that contain medicinal herb instead of metal nanoparticles to impart antibacterial or other desirable properties. Herein, a novel multicomponent nanofibrous mat has been successfully prepared by electrospinning technique from a blended solution of polyvinyl alcohol, honey and Curcumin longa (turmeric) extract for potential application as the wound dressing material. Ethyl acetate extraction was followed to obtain the restorative components of turmeric. The fabricated nanofibrous materials were characterized by scanning electron microscope, moisture management tester, bacterial assay and Fourier-transform infrared spectroscopy (FTIR) to evaluate their morphological, moisture, antibacterial and chemical behavior, respectively. Nanofibers of fabricated mat show an average diameter of 340 nm with better moisture management properties compared to polyvinyl alcohol nanomat alone. The agar diffusion method has been used to evaluate the antibacterial activity against Staphylococcus aureus bacteria showing the formation of inhibition zone with a value of 29 mm and 38 mm. The presence of characteristic peaks in Fourier-transform infrared spectra reveals that all the desired components are present in the developed nanofibrous mats.

Automated summary

A novel multicomponent nanofibrous mat containing polyvinyl alcohol, honey and Curcumin longa extract was successfully prepared, showing better moisture management properties and antibacterial activity. Characterization by scanning electron microscope, bacterial assay, moisture management tester, and FTIR revealed the presence of desired components and promising properties of the fabricated nanofibrous mats.