期刊
JOURNAL OF HEPATOLOGY
卷 72, 期 1, 页码 183-196出版社
ELSEVIER
DOI: 10.1016/j.jhep.2019.08.026
关键词
Aggrephagy; Chaperone-mediated autophagy; Lipid droplets; Lipophagy; Mitophagy; Unfolded protein response
资金
- FONDECYT [3180427, 1140549, 1180186]
- Breakthrough Level 2 grant from the US DoD, Breast Cancer Research Program (BCRP) [BC180476P1]
- Dept. of Radiation Oncology at Weill Cornell Medicine (New York, US)
- Lytix (Oslo, Norway)
- Phosplatin (New York, US)
- FONDAP program [15150012]
- Millennium Institute [P09-015-F]
- European Commission RD MSCA-RISE [734749]
- Michael J Fox Foundation for Parkinson's Research - Target Validation grant [9277]
- FONDEF [ID16I10223, D11E1007]
- US Office of Naval Research -Global (ONR-G) [N62909-16-1-2003]
- U.S. Air Force Office of Scientific Research [FA9550-16-1-0384]
- ALSRP Therapeutic Idea Award [AL150111]
- Muscular Dystrophy Association [382453]
- CONICYT Brazil [441921/2016-7]
- Ligue contre le Cancer (equipe labellisee)
- Agence National de la Recherche (ANR) - Projets blancs
- ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ilede-France
- Chancelerie des universites de Paris (Legs Poix), Fondation pour la Recherche Medicale (FRM)
- European Research Area Network on Cardiovascular Diseases (ERACVD, MINOTAUR)
- Gustave Roussy Odyssea, the European Union Horizon 2020 Project Oncobiome
- Fondation Carrefour
- High-end Foreign Expert Program in China, Institut National du Cancer (INCa) [GDW20171100085, GDW20181100051]
- Inserm (HTE)
- Inserm Transfert, Institut Universitaire de France
- LeDucq Foundation
- LabEx Immuno-Oncology
- RHU Torino Lumiere
- Seerave Foundation
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support bioenergetic metabolism and adapt to stress. Accumulating evidence indicates that autophagy operates as a critical quality control mechanism for the maintenance of hepatic homeostasis in both parenchymal (hepatocytes) and non-parenchymal (stellate cells, sinusoidal endothelial cells, Kupffer cells) compartments. In line with this notion, insufficient autophagy has been aetiologically involved in the pathogenesis of multiple liver disorders, including alpha-1-antitrypsin deficiency, Wilson disease, non-alcoholic steatohepatitis, liver fibrosis and hepatocellular carcinoma. Here, we critically discuss the importance of functional autophagy for hepatic physiology, as well as the mechanisms whereby defects in autophagy cause liver disease. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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