相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses
Sarah Spencer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
Identification of a T follicular helper cell subset that drives anaphylactic IgE
Uthaman Gowthaman et al.
SCIENCE (2019)
International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity
Capucine Picard et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2018)
B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation
Alexandra M. Miggelbrink et al.
BLOOD (2018)
Self-Reactive B Cells in the Germinal Center Reaction
Robert Brink et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)
T Follicular Helper Cells in Autoimmune Disorders
Noemie Gensous et al.
FRONTIERS IN IMMUNOLOGY (2018)
Type I Interferons in Autoimmune Disease
Mary K. Crow et al.
Annual Review of Pathology-Mechanisms of Disease (2018)
Control of Germinal Center Responses by T-Follicular Regulatory Cells
James B. Wing et al.
FRONTIERS IN IMMUNOLOGY (2018)
Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions
David G. Gonzalez et al.
JOURNAL OF IMMUNOLOGY (2018)
Interleukin 30 to Interleukin 40
Jovani Catalan-Dibene et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2018)
Regulation of the Germinal Center Response
Marisa Stebegg et al.
FRONTIERS IN IMMUNOLOGY (2018)
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
Vivien Beziat et al.
SCIENCE IMMUNOLOGY (2018)
ZNF341 controls STAT3 expression and thereby immunocompetence
Stefanie Frey-Jakobs et al.
SCIENCE IMMUNOLOGY (2018)
Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells
Stuart G. Tangye et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao et al.
NATURE (2017)
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
Christoph Jandl et al.
NATURE COMMUNICATIONS (2017)
Attenuation of Follicular Helper T Cell-Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjogren's Syndrome
Gwenny M. Verstappen et al.
ARTHRITIS & RHEUMATOLOGY (2017)
A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjogren's syndrome and systemic lupus erythematosus
K. Szabo et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2016)
The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses
Chun Chou et al.
IMMUNITY (2016)
B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome
Alisa Kane et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
Mubeccel Akdis et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
Cindy S. Ma et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
Suppression by TFR\ cells leads to durable and selective inhibition of B cell effector function
Peter T. Sage et al.
NATURE IMMUNOLOGY (2016)
TFH cells progressively differentiate to regulate the germinal center response
Jason S. Weinstein et al.
NATURE IMMUNOLOGY (2016)
Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice
Koji Sakuraba et al.
ARTHRITIS RESEARCH & THERAPY (2016)
Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R
Baran Erman et al.
HAEMATOLOGICA (2015)
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
Cindy S. Ma et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)
An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells
Hao Wu et al.
JOURNAL OF IMMUNOLOGY (2015)
Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity
James A. Harker et al.
JOURNAL OF IMMUNOLOGY (2015)
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection
Brodie Miles et al.
NATURE COMMUNICATIONS (2015)
Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R
Baran Erman et al.
HAEMATOLOGICA (2015)
Interleukin-21 Receptor Blockade Inhibits Secondary Humoral Responses and Halts the Progression of Preestablished Disease in the (NZB x NZW)F1 Systemic Lupus Erythematosus Model
Ming Zhang et al.
ARTHRITIS & RHEUMATOLOGY (2015)
T-cell STAT3 is required for the maintenance of humoral immunity to LCMV
David R. McIlwain et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2015)
Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency
Polina Stepensky et al.
HAEMATOLOGICA (2015)
Follicular helper T cell signature in type 1 diabetes
Rupert Kenefeck et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Circulating CCR7+ICOS+ Memory T Follicular Helper Cells in Patients with Multiple Sclerosis
Xueli Fan et al.
PLOS ONE (2015)
The generation of antibody-secreting plasma cells
Stephen L. Nutt et al.
NATURE REVIEWS IMMUNOLOGY (2015)
Human IL-21 and IL-21R deficiencies: two novel entities of primary immunodeficiency
Daniel Kotlarz et al.
CURRENT OPINION IN PEDIATRICS (2014)
Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells
John P. Ray et al.
IMMUNITY (2014)
T Follicular Helper Cell Differentiation, Function, and Roles in Disease
Shane Crotty
IMMUNITY (2014)
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency
Elisabeth Salzer et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)
Circulating T follicular regulatory and helper cells have memory-like properties
Peter T. Sage et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
IL-21 Contributes to Fatal Inflammatory Disease in the Absence of Foxp3+ T Regulatory Cells
Alexis Vogelzang et al.
JOURNAL OF IMMUNOLOGY (2014)
IL-21 Promotes CD4 T Cell Responses by Phosphatidylinositol 3-Kinase-Dependent Upregulation of CD86 on B Cells
Kesley Attridge et al.
JOURNAL OF IMMUNOLOGY (2014)
Increased Interleukin 21 and Follicular Helper T-like Cells and Reduced Interleukin 10+B cells in Patients with New-onset Systemic Lupus Erythematosus
Li Wang et al.
JOURNAL OF RHEUMATOLOGY (2014)
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
Nathalie Schmitt et al.
NATURE IMMUNOLOGY (2014)
Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice
Yanna Ding et al.
ARTHRITIS & RHEUMATOLOGY (2014)
Cytokine-meciated regulation of plasma cell generation: IL-21 takes center stage
Leen Moens et al.
FRONTIERS IN IMMUNOLOGY (2014)
IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts
Lucinda J. Berglund et al.
BLOOD (2013)
IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans
Nathalie Schmitt et al.
BLOOD (2013)
Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure
Jing He et al.
IMMUNITY (2013)
Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency
Fabienne Mazerolles et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome
Daniel Kotlarz et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
Elissa K. Deenick et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus-like Disease of BXSB.Yaa Mice
Caroline G. McPhee et al.
JOURNAL OF IMMUNOLOGY (2013)
IL-21-Producing Th Cells in Immunity and Autoimmunity
Sue M. Liu et al.
JOURNAL OF IMMUNOLOGY (2013)
Interleukin-21 Is a Critical Cytokine for the Generation of Virus-Specific Long-Lived Plasma Cells
Mohammed Ata Ur Rasheed et al.
JOURNAL OF VIROLOGY (2013)
Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17-and Activated B-Cells and Correlates with Progression
Jeppe Romme Christensen et al.
PLOS ONE (2013)
Circulating TFH Subset Distribution Is Strongly Affected in Lupus Patients with an Active Disease
Carole Le Coz et al.
PLOS ONE (2013)
Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes
Xinyu Xu et al.
PLOS ONE (2013)
IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection
Iwana Schmitz et al.
PLOS PATHOGENS (2013)
The good, the bad and the ugly - TFH cells in human health and disease
Stuart G. Tangye et al.
NATURE REVIEWS IMMUNOLOGY (2013)
Germinal Centers
Gabriel D. Victora et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)
Regulatory T Cells: Mechanisms of Differentiation and Function
Steven Z. Josefowicz et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)
IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis
Kesley Attridge et al.
BLOOD (2012)
Functional STAT3 deficiency compromises the generation of human T follicular helper cells
Cindy S. Ma et al.
BLOOD (2012)
IL-6 Triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells
Sean A. Diehl et al.
IMMUNOLOGY AND CELL BIOLOGY (2012)
The origins, function, and regulation of T follicular helper cells
Cindy S. Ma et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
Alex Karnowski et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Cutting Edge: IL-21 Derived from Human Follicular Helper T Cells Acts as a Survival Factor for Secondary Lymphoid Organ, but Not for Bone Marrow, Plasma Cells
Beatriz Rodriguez-Bayona et al.
JOURNAL OF IMMUNOLOGY (2012)
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice
Andrew L. Rankin et al.
JOURNAL OF IMMUNOLOGY (2012)
Interleukin 21 Correlates with T Cell and B Cell Subset Alterations in Systemic Lupus Erythematosus
Benjamin Terrier et al.
JOURNAL OF RHEUMATOLOGY (2012)
Inhibition of Aberrant Circulating Tfh Cell Proportions by Corticosteroids in Patients with Systemic Lupus Erythematosus
Xuebing Feng et al.
PLOS ONE (2012)
A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis
Rui Liu et al.
ARTHRITIS RESEARCH & THERAPY (2012)
Follicular Helper CD4 T Cells (T-FH)
Shane Crotty
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo
Mike Recher et al.
BLOOD (2011)
Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
Helen M. McGuire et al.
DIABETES (2011)
Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion
Rimpei Morita et al.
IMMUNITY (2011)
IL-21 Receptor Is Critical for the Development of Memory B Cell Responses
Andrew L. Rankin et al.
JOURNAL OF IMMUNOLOGY (2011)
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
Danelle Eto et al.
PLOS ONE (2011)
Key role for IL-21 in experimental autoimmune uveitis
Lu Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus
Sebastian Dolff et al.
ARTHRITIS RESEARCH & THERAPY (2011)
Expansion of Circulating T Cells Resembling Follicular Helper T Cells Is a Fixed Phenotype That Identifies a Subset of Severe Systemic Lupus Erythematosus
Nicholas Simpson et al.
ARTHRITIS AND RHEUMATISM (2010)
Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells
Santi Suryani et al.
BLOOD (2010)
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
Marcel Batten et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
Danielle T. Avery et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
Michelle A. Linterman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
Dimitra Zotos et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Cutting Edge: IL-21 and TLR Signaling Regulate Germinal Center Responses in a B Cell-Intrinsic Manner
Juliana Bessa et al.
JOURNAL OF IMMUNOLOGY (2010)
A Nonredundant Role for IL-21 Receptor Signaling in Plasma Cell Differentiation and Protective Type 2 Immunity against Gastrointestinal Helminth Infection
Irah L. King et al.
JOURNAL OF IMMUNOLOGY (2010)
Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells
John J. O'Shea et al.
SCIENCE (2010)
Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice
Andrew P. R. Sutherland et al.
DIABETES (2009)
Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12
Nathalie Schmitt et al.
IMMUNITY (2009)
Early commitment of naive human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL-12
Cindy S. Ma et al.
IMMUNOLOGY AND CELL BIOLOGY (2009)
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
Oliver Dienz et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25- T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice
Eunkyeong Jang et al.
JOURNAL OF IMMUNOLOGY (2009)
Cytokine-secreting follicular T cells shape the antibody repertoire
R. Lee Reinhardt et al.
NATURE IMMUNOLOGY (2009)
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
Jason A. Bubier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A fundamental role for interleukin-21 in the generation of T follicular helper cells
Alexis Vogelzang et al.
IMMUNITY (2008)
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
Roza I. Nurieva et al.
IMMUNITY (2008)
Development and characterization of IL-21-producing CD4+ T cells
Akira Suto et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
STAT3-mediated up-regulation of BLIMP1 is coordinated with BCL6 down-regulation to control human plasma cell differentiation
Sean A. Diehl et al.
JOURNAL OF IMMUNOLOGY (2008)
IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4
Danielle T. Avery et al.
JOURNAL OF IMMUNOLOGY (2008)
IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
Rosanne Spolski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells:: Predominant role of IL-21 produced by CXCR5+ T follicular helper cells
Vanessa L. Bryant et al.
JOURNAL OF IMMUNOLOGY (2007)
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
Stefan Kuchen et al.
JOURNAL OF IMMUNOLOGY (2007)
STAT3 mutations in the hyper-IgE syndrome
Steven M. Holland et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Yoshiyuki Minegishi et al.
NATURE (2007)
Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
Deborah A. Young et al.
ARTHRITIS AND RHEUMATISM (2007)
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
Deborah Herber et al.
JOURNAL OF IMMUNOLOGY (2007)
IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells
Rachel Ettinger et al.
JOURNAL OF IMMUNOLOGY (2007)
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
Kim L. Good et al.
JOURNAL OF IMMUNOLOGY (2006)
BAFF, APRIL and human B cell disorders
Stuart G. Tangye et al.
SEMINARS IN IMMUNOLOGY (2006)
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
Srividya Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-γ-deficient mice in a Th2-biased response
X. Z. Shang et al.
CELLULAR IMMUNOLOGY (2006)
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
JL Fornek et al.
BLOOD (2006)
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
R Ettinger et al.
JOURNAL OF IMMUNOLOGY (2005)
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
CG Vinuesa et al.
NATURE (2005)
Interleukin-7 receptor α (IL-7Rα) deficiency:: cellular and molecular bases.: Analysis of clinical, immunological, and molecular features in 16 novel patients
S Giliani et al.
IMMUNOLOGICAL REVIEWS (2005)
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
T Chtanova et al.
JOURNAL OF IMMUNOLOGY (2004)
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of blimp-1 and bcl-61
K Ozaki et al.
JOURNAL OF IMMUNOLOGY (2004)
Cutting edge:: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells
J Pène et al.
JOURNAL OF IMMUNOLOGY (2004)
Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cε transcription of IL-4-stimulated B cells
A Suto et al.
BLOOD (2002)
A critical role for IL-21 in regulating immunoglobulin production
K Ozaki et al.
SCIENCE (2002)
Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells
H Toyama et al.
IMMUNITY (2002)
The common γ chain (γc) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3
T Habib et al.
BIOCHEMISTRY (2002)
Cytokines and immunodeficiency diseases
WJ Leonard
NATURE REVIEWS IMMUNOLOGY (2001)
Cutting edge:: The common γ-chain is an indispensable subunit of the IL-21 receptor complex
H Asao et al.
JOURNAL OF IMMUNOLOGY (2001)
The TNF and TNF receptor superfamilies: Integrating mammalian biology
RM Locksley et al.
CELL (2001)
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
J Parrish-Novak et al.
NATURE (2000)
Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain
K Ozaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
分享论文
