期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 54, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2019.101310
关键词
Orally disintegrating film; Disintegration time; Insoluble particle; Hydroxypropyl methylcellulose; Silica
The most important issue in the design of orally disintegrating films (ODFs) is the control of the ODFs' disintegration properties. A better understanding of the mechanisms of ingredients used to promote or disturb the disintegration time of ODFs would improve the development of ODF formulations. Here we focused on the advantage of adding insoluble particles (IPs) to improve the disintegration times of ODFs. We also verified the undesirable impact of the use of IPs on the mechanical properties of ODFs. We used hydroxyproplyl methylcellulose (HPMC), which is one of the most commonly used film-forming polymers for ODFs, as a film former. Films were prepared using the solution/solvent casting method. Microcrystalline cellulose, low-substituted hydroxypropyl cellulose, and silica with different particle sizes and shapes were added in the film formulations as IPs. As expected, the addition of IPs shortened the disintegration times of the films. The larger particles had a greater impact compared to the smaller particles. However, the addition of larger particles decreased the films' tensile strength. Our results demonstrate the effectiveness of IPs for shortening the disintegration times of HPMC films loaded with active pharmaceutical ingredients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据