期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 33, 期 1, 页码 146-149出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2020.1729952
关键词
Vitiligo; Tacrolimus 0; 1%; pseudocatalase; superoxide dismutase (PSD); catalase
类别
资金
- deanship of research at Jordan University of Science and Technology [10/114/2018]
This study aimed to assess the synergic effect of pseudocatalase/superoxide dismutase (PSD) gel when combined with Tacrolimus 0.1% ointment versus Tacrolimus 0.1% alone for the treatment of vitiligo. The results showed that adding PSD to Tacrolimus ointment did not provide any additional therapeutic benefit in children with limited vitiligo.
Background: The pathogenesis of vitiligo is complex and multifactorial, accumulating evidence of increased oxidative stress and reduction in catalase levels in vitiligo patients has been shown, hence, pseudocatalase/superoxide dismutase (PSD) gel has been used as treatment option for vitiligo. Aim: To assesses the synergic effect of PSD when combines with Tacrolimus 0.1% ointment versus Tacrolimus 0.1% alone. Method: A randomized controlled trial that included 49 children with vitiligo with limited area (10% or less). Patients were randomized into two groups: Group 1 (24 patients) were treated only with Tacrolimus 0.1% ointment whereas Group 2 (25 patients) were treated with Tacrolimus 0.1% ointment plus PSD. Degree of repigmentation compared to baseline was assessed at 3, 6, and 9 months. Results: The median age was 10.05 years (range 2-18). The percentages of pigmentation on 3, 6, and 9 months for Group 1 were 23.9%, 40.4%, and 60%, respectively and for Group 2 were 23.2%, 40.7%, and 62.4%, respectively. There was no significant difference according to repigmentation percentages between the two groups (p > .86, p > .97, and p > .78, respectively). Conclusions: The results showed that the addition of PSD to Tacrolimus ointment in children with limited vitiligo was not associated with any therapeutic benefit.
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