期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 209, 期 3, 页码 216-221出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.115.171975
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资金
- Lundbeck Foundation, within Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Mental Health in Primary Care (MEPRICA)
- Mental Health Services, Capital Region, Copenhagen, Denmark
- Stanley Medical Research Institute
- Lundbeck Foundation, within Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
- Mental Health in Primary Care (MEPRICA)
- Mental Health Services, Capital Region, Copenhagen, Denmark
- Stanley Medical Research Institute
- Lundbeck Foundation [R155-2012-11280, R155-2014-1724] Funding Source: researchfish
Background Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. Aims To assess mortality risk in people with anxiety disorders. Method We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up. Results In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR)=1.39, 95% CI 1.28-1.51; unnatural MRR=2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR=11.72, 95% CI 10.11-13.51). Conclusions Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
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