P. domestica Extract Mediated Silver Nanoparticles and their Antinociceptive Activity for Pain Management in Children

Because of the environmentally-friendly design and low cost, bio-mediated synthesis of nanoparticles has become popular in recent years. In this research, we utilized an aqueous extract of Prunus domestica (P. domestica) to produce silver nanoparticles (AgNPs). Different spectroscopic and microscopic studies have performed to characterize the as-produced AgNPs. The X-ray diffraction (XRD) findings showed the formation of crystalline face-centered cubic (fcc) NPs. Furthermore, the analysis of Fourier transform infrared (FT-IR) spectroscopy verified that the P. domestica leaf extract not only worked as a bioreducing agent and also capped the AgNP surface by serving as a stabilizing agent. The prepared AgNPs were tested for their antinociceptive (abdominal constriction response) activities. It was revealed that AgNPs suggestively reduced the chemically-persuaded nociception, which was equivalent to the effect of P. domestica extract. Further, these results conclude the use of P. domestica extract mediated AgNPs as antinociceptive agent for pain management in children.

Automated summary

The study successfully synthesized silver nanoparticles using Prunus domestica extract and demonstrated their analgesic properties, suggesting their potential use in pediatric pain management.