期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 173, 期 18, 页码 2702-2725出版社
WILEY
DOI: 10.1111/bph.13536
关键词
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资金
- Agence Nationale de la Recherche [ANR 2011 -BSV1-012-01]
- Agence Nationale de la Recherche (ANR-META 'MELA-BETES') [ANR-12-RPIB-0016]
- Fondation de la Recherche Medicale [FRM DEQ20130326503]
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Centre National de la Recherche Scientifique (CNRS)
- 'Who am I?' laboratory of excellence - French Government through 'Investments for the Future' programme [ANR-11-LABX-0071]
- French National Research Agency (ANR) [ANR-11-IDEX-0005-01]
- USPHS [MH-42922, MH 52685, DA021870, NS 061068]
- National Institutes of Health [EY022216, EY020821]
- Sao Paulo Research Foundation (FAPESP - Thematic Project) [2013/13691-1]
- Brazilian National Council of Research and Innovation (CNPq) [480097]
- Wellcome Trust
- [5U54NS083932]
- [S21MD000101]
- [G12-RR03034]
- [U54RR026137]
- Agence Nationale de la Recherche (ANR) [ANR-12-RPIB-0016] Funding Source: Agence Nationale de la Recherche (ANR)
Melatonin receptors are seven transmembrane-spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist - MT1 and MT2 - encoded by the MTNR1A and MTNR1B genes respectively. The current review provides an update on melatonin receptors by the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology. We will highlight recent developments of melatonin receptor ligands, including radioligands, and give an update on the latest phenotyping results of melatonin receptor knockout mice. The current status and perspectives of the structure of melatonin receptor will be summarized. The physiological importance of melatonin receptor dimers and biologically important and type 2 diabetes-associated genetic variants of melatonin receptors will be discussed. The role of melatonin receptors in physiology and disease will be further exemplified by their functions in the immune system and the CNS. Finally, antioxidant and free radical scavenger properties of melatonin and its relation to melatonin receptors will be critically addressed.
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