4.7 Review

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Toxicology

Cardiotoxicity screening: a review of rapid-throughput in vitro approaches

Xichun Li et al.

ARCHIVES OF TOXICOLOGY (2016)

Editorial Material Cardiac & Cardiovascular Systems

Genetic screening in acquired long QT syndrome? CAUTION: proceed carefully

Ahmad S. Amin et al.

EUROPEAN HEART JOURNAL (2016)

Article Cardiac & Cardiovascular Systems

The genetics underlying acquired long QT syndrome: impact for genetic screening

Hideki Itoh et al.

EUROPEAN HEART JOURNAL (2016)

Article Biochemistry & Molecular Biology

WITHDRAWN-a resource for withdrawn and discontinued drugs

Vishal B. Siramshetty et al.

NUCLEIC ACIDS RESEARCH (2016)

Review Pharmacology & Pharmacy

Human engineered heart tissue as a model system for drug testing

Alexandra Eder et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Cardiac & Cardiovascular Systems

IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes

Ravi Vaidyanathan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

High-throughput drug profiling with voltage-and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes

Stephane Bedut et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction

Daniela Malan et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

Article Biochemistry & Molecular Biology

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform

Chris Denning et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Cardiac & Cardiovascular Systems

Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias

Zhiyi Yu et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2016)

Review Pediatrics

Cystic fibrosis: a model system for precision medicine

Stacey L. Martiniano et al.

CURRENT OPINION IN PEDIATRICS (2016)

Review Cell Biology

Generation and purification of human stem cell-derived cardiomyocytes

Verena Schwach et al.

DIFFERENTIATION (2016)

Article Cardiac & Cardiovascular Systems

Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs

Valentina Mercurio et al.

JOURNAL OF CARDIAC FAILURE (2016)

Review Cardiac & Cardiovascular Systems

Predicting the Unpredictable Drug-Induced QT Prolongation and Torsades de Pointes

Peter J. Schwartz et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

Article Biochemical Research Methods

A high-content platform to characterise human induced pluripotent stem cell lines

Andreas Leha et al.

METHODS (2016)

Editorial Material Cardiac & Cardiovascular Systems

The cancer's gone, but did chemotherapy damage your heart?

Milena Bellin et al.

NATURE REVIEWS CARDIOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

Ian Y. Chen et al.

NATURE REVIEWS CARDIOLOGY (2016)

Article Biotechnology & Applied Microbiology

Evolution of strategies to improve preclinical cardiac safety testing

Gary Gintant et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Review Cell Biology

Pluripotent stem cells in disease modelling and drug discovery

Yishai Avior et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology

Aleksandra Klimas et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

Agnes Maillet et al.

SCIENTIFIC REPORTS (2016)

Article Pharmacology & Pharmacy

Safety pharmacology studies using EFP and impedance

Alison Obergrussberger et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)

Article Pharmacology & Pharmacy

Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging

Graham T. Dempsey et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)

Article Pharmacology & Pharmacy

Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation

Icilio Cavero et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)

Article Pharmacology & Pharmacy

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

William J. Crumb et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)

Review Biochemical Research Methods

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Bernard Fermini et al.

JOURNAL OF BIOMOLECULAR SCREENING (2016)

Review Cardiac & Cardiovascular Systems

Drug-induced mitochondrial dysfunction and cardiotoxicity

Zoltan V. Varga et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Review Genetics & Heredity

Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine

Paul W. Burridge et al.

ANNUAL REVIEW OF GENETICS, VOL 49 (2015)

Article Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Transporters

Stephen P. H. Alexander et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

M. J. Cross et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Voltage-gated ion channels

Stephen P. H. Alexander et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy

Daniela Cardinale et al.

CIRCULATION (2015)

Article Cardiac & Cardiovascular Systems

Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator

Mei-Ling Chang Liao et al.

CIRCULATION RESEARCH (2015)

Article Cardiac & Cardiovascular Systems

IKr Impact on Repolarization and Its Variability Assessed by Dynamic Clamp

Claudia Altomare et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2015)

Editorial Material Biotechnology & Applied Microbiology

Regulating the therapeutic translation of regenerative medicine

Maude L. Cuchiara et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

Article Cardiac & Cardiovascular Systems

Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells

Jong J. Kim et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Letter Cardiac & Cardiovascular Systems

Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full

Hyun Seok Hwang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Letter Cardiac & Cardiovascular Systems

Induced pluripotent stem cell-derived cardiac myocytes to understand and test calcium handling: Pie in the sky?

Christopher Kane et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories

Hyun Seok Hwang et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Review Cardiac & Cardiovascular Systems

Cardiotoxicity of anticancer treatments

Michael S. Ewer et al.

NATURE REVIEWS CARDIOLOGY (2015)

Article Biotechnology & Applied Microbiology

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Michael J. Waring et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Editorial Material Medicine, General & Internal

A New Initiative on Precision Medicine

Francis S. Collins et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Alexandre J. S. Ribeiro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Cell & Tissue Engineering

Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?

Christiaan C. Veerman et al.

STEM CELLS AND DEVELOPMENT (2015)

Article Cell & Tissue Engineering

Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes

Philippe Beauchamp et al.

TISSUE ENGINEERING PART C-METHODS (2015)

Article Biochemical Research Methods

Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation

Tadashi Miyamoto et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

Article Medicine, Research & Experimental

Personalized Genomes and Cardiovascular Disease

Kiran Musunuru

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Biochemical Research Methods

Action Potential Characterization of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using Automated Patch-Clamp Technology

Olaf Scheel et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2014)

Article Cardiac & Cardiovascular Systems

Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes

Ashish Mehta et al.

CARDIOVASCULAR RESEARCH (2014)

Review Cardiac & Cardiovascular Systems

Genetically Encoded Ca2+ Indicators in Cardiac Myocytes

Lars Kaestner et al.

CIRCULATION RESEARCH (2014)

Article Cardiac & Cardiovascular Systems

AKAP9 Is a Genetic Modifier of Congenital Long-QT Syndrome Type 1

Carin P. de Villiers et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2014)

Review Pharmacology & Pharmacy

Induced pluripotent stem cells as cardiac arrhythmic in vitro models and the impact for drug discovery

Tomo Saric et al.

EXPERT OPINION ON DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium

Irene C. Turnbull et al.

FASEB JOURNAL (2014)

Article Cardiac & Cardiovascular Systems

Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation

Marc N. Hirt et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

Review Cardiac & Cardiovascular Systems

Prevention of Anthracycline-Induced Cardiotoxicity

Pimprapa Vejpongsa et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Clinical development success rates for investigational drugs

Michael Hay et al.

NATURE BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

CRISPR-Cas systems for editing, regulating and targeting genomes

Jeffry D. Sander et al.

NATURE BIOTECHNOLOGY (2014)

Article Biochemical Research Methods

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

Daniel R. Hochbaum et al.

NATURE METHODS (2014)

Article Biochemical Research Methods

Chemically defined generation of human cardiomyocytes

Paul W. Burridge et al.

NATURE METHODS (2014)

Article Biotechnology & Applied Microbiology

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

David Cook et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Multidisciplinary Sciences

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue

Miao Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Optical mapping of optogenetically shaped cardiac action potentials

Sarah A. Park et al.

SCIENTIFIC REPORTS (2014)

Article Engineering, Biomedical

Three-Dimensional Paper-Based Model for Cardiac Ischemia

Bobak Mosadegh et al.

ADVANCED HEALTHCARE MATERIALS (2014)

Article Medicine, General & Internal

Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study

Henrik Svanstrom et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

Article Pharmacology & Pharmacy

Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents

John K. Gibson et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2014)

Article Multidisciplinary Sciences

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry

Subarna Bhattacharya et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2014)

Article Engineering, Biomedical

Computational Models of Ventricular- and Atrial-Like Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

Michelangelo Paci et al.

ANNALS OF BIOMEDICAL ENGINEERING (2013)

Article Cardiac & Cardiovascular Systems

Identification of a KCNQ1 Polymorphism Acting as a Protective Modifier Against Arrhythmic Risk in Long-QT Syndrome

Sabine Duchatelet et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2013)

Article Biochemistry & Molecular Biology

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome

Milena Bellin et al.

EMBO JOURNAL (2013)

Article Cardiac & Cardiovascular Systems

Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells

Dongrui Ma et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

Article Biochemical Research Methods

Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes

Sara S. Nunes et al.

NATURE METHODS (2013)

Review Nanoscience & Nanotechnology

Multi-electrode array technologies for neuroscience and cardiology

Micha E. Spira et al.

NATURE NANOTECHNOLOGY (2013)

Review Cardiac & Cardiovascular Systems

Assessing cardiovascular drug safety for clinical decision-making

Raymond L. Woosley et al.

NATURE REVIEWS CARDIOLOGY (2013)

Article Cell & Tissue Engineering

Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes

Alexandra Bizy et al.

STEM CELL RESEARCH (2013)

Review Cell & Tissue Engineering

Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Claire Robertson et al.

STEM CELLS (2013)

Article Cardiac & Cardiovascular Systems

Electrical Stimulation Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells

Yau-Chi Chan et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2013)

Article Multidisciplinary Sciences

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

James Kramer et al.

SCIENTIFIC REPORTS (2013)

Article Pharmacology & Pharmacy

Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: Effects of reference compounds

Herbert M. Himmel

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2013)

Article Cardiac & Cardiovascular Systems

Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species

Thomas O'Hara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

Article Engineering, Biomedical

Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes

Michelangelo Paci et al.

BIOMEDICAL ENGINEERING ONLINE (2012)

Editorial Material Cardiac & Cardiovascular Systems

Personalized medicine and the role of induced pluripotent stem cells

Marcel A. G. van der Heyden et al.

CARDIOVASCULAR RESEARCH (2012)

Review Cardiac & Cardiovascular Systems

Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues

Todd J. Herron et al.

CIRCULATION RESEARCH (2012)

Review Cardiac & Cardiovascular Systems

Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells to Cardiomyocytes A Methods Overview

Christine L. Mummery et al.

CIRCULATION RESEARCH (2012)

Article Cardiac & Cardiovascular Systems

Practice and challenges of thorough QT studies

Norman Stockbridge et al.

JOURNAL OF ELECTROCARDIOLOGY (2012)

Review Cell Biology

Induced pluripotent stem cells: the new patient?

Milena Bellin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

Hongkang Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Pharmacology & Pharmacy

Quickly finding a needle in a haystack: A new automated cardiac arrhythmia detection software for preclinical studies

Florence Koeppel et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2012)

Review Physiology

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythrnias

Maaike Hoekstra et al.

FRONTIERS IN PHYSIOLOGY (2012)

Review Pharmacology & Pharmacy

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

H. G. Laverty et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Pharmacological Activation of Kv11.1 in Transgenic Long QT-1 Rabbits

Bo Hjorth Bentzen et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2011)

Article Multidisciplinary Sciences

Modelling the long QT syndrome with induced pluripotent stem cells

Ilanit Itzhaki et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Getting pharmaceutical R&D back on target

Mark E. Bunnage

NATURE CHEMICAL BIOLOGY (2011)

Article Biochemical Research Methods

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Thomas O'Hara et al.

PLOS COMPUTATIONAL BIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Cell Communications in the Heart

Daniela Tirziu et al.

CIRCULATION (2010)

Review Oncology

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

Adriana Albini et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

Article Biophysics

Anthropomorphizing the Mouse Cardiac Action Potential via a Novel Dynamic Clamp Method

Rebecca C. Ahrens-Nicklas et al.

BIOPHYSICAL JOURNAL (2009)

Review Sport Sciences

QTc: how long is too long?

J. N. Johnson et al.

BRITISH JOURNAL OF SPORTS MEDICINE (2009)

Review Pharmacology & Pharmacy

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

Jules C. Hancox et al.

PHARMACOLOGY & THERAPEUTICS (2008)

Review Genetics & Heredity

The clinical role of genetic polymorphisms in drug-metabolizing enzymes

D. Tomalik-Scharte et al.

PHARMACOGENOMICS JOURNAL (2008)

Review Biochemistry & Molecular Biology

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

Marcella Martignoni et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)

Article Cardiac & Cardiovascular Systems

Genotype-specific onset of arrhythmias in congenital long-QT syndrome - Possible therapy implications

Hanno L. Tan et al.

CIRCULATION (2006)

Review Pharmacology & Pharmacy

Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics

Daniel W. Nebert et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2006)

Article Cardiac & Cardiovascular Systems

Mapping arrhythmias in the failing heart: from Langendorff to patient

Joseph G. Akar et al.

JOURNAL OF ELECTROCARDIOLOGY (2006)

Review Multidisciplinary Sciences

hERG potassium channels and cardiac arrhythmia

MC Sanguinetti et al.

NATURE (2006)

Review Cardiac & Cardiovascular Systems

Animal models for arrhythmias

DJ Milan et al.

CARDIOVASCULAR RESEARCH (2005)

Review Cardiac & Cardiovascular Systems

Studying cardiac arrhythmias in the mouse - A reasonable model for probing mechanisms?

JM Nerbonne

TRENDS IN CARDIOVASCULAR MEDICINE (2004)

Article Cardiac & Cardiovascular Systems

QT variability

RD Berger

JOURNAL OF ELECTROCARDIOLOGY (2003)

Article Infectious Diseases

Cardiotoxicity of fluoroquinolones

E Rubinstein et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2002)

Article Cardiac & Cardiovascular Systems

Tissue engineering of a differentiated cardiac muscle construct

WH Zimmermann et al.

CIRCULATION RESEARCH (2002)

Review Biotechnology & Applied Microbiology

The genetic basis of variability in drug responses

DM Roden et al.

NATURE REVIEWS DRUG DISCOVERY (2002)