期刊
出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2020.122039
关键词
Nanocrystalline cellulose; Thin film microextraction; Bio-templating; Titania; Nonsteroidal anti-inflammatory drugs
资金
- University of Mazandaran
The present study included the procedure of preparing porous titania thin film using a direct nanocrystalline cellulose templating (NCC) as a bio-template. The microextraction applicability of the porous film was investigated by thin film microextraction (TFME) of the nonsteroidal anti-inflammatory drugs (NSAIDs) including ketorolac, meloxicam, diclofenac and mefenamic acid from different types of urine sample. The extracted NSAIDs were analyzed by HPLC-UV. Under optimum conditions, the calibration curves were linear within the range of 1.0-500 mu g L-1 (2.0-200 mu g L-1 for ketorolac, 2.0-500 mu g L-1 for meloxicam, 1.0-200 mu g L-1 for diclofenac and 1.0-200 mu g L-1 for mefenamic acid). The limit of detection was found to be between 0.2 and 0.5 mu g L-1. The calculated intra- and inter-day relative standard deviations RSDs% (n = 3) at concentration level of 10 mu g L-1 were less than 6.3% and 6.0%, respectively. Finally, the method was successfully applied to determine selected NSAIDs in urine samples from different human individuals.
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