期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 174, 期 10, 页码 1025-1033出版社
WILEY
DOI: 10.1111/bph.13559
关键词
-
资金
- Natural Sciences and Engineering Council of Canada (NSERC)
- Dept. of Surgery Research Fund, University of Manitoba
We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors.
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