期刊
JOURNAL OF CHEMICAL INFORMATION AND MODELING
卷 60, 期 5, 页码 2424-2429出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jcim.9b01164
关键词
-
类别
资金
- Welch Foundation [F-1938, F-1515]
- Army Research Office [W911NF-15-1-0120, W911NF-19-1-0021]
- Robert J. Kleberg, Jr., and Helen C. Kleberg Foundation Medical Research Award
- National Institutes of Health [GM122480, DK110520, HD085901]
- National Science Foundation [2019238253]
- Cancer Prevention and Research Institute of Texas [RR160088]
Rapid developments in cryogenic electron microscopy have opened new avenues to probe the structures of protein assemblies in their near native states. Recent studies have begun applying single-particle analysis to heterogeneous mixtures, revealing the potential of structural-omics approaches that combine the power of mass spectrometry and electron microscopy. Here we highlight advances and challenges in sample preparation, data processing, and molecular modeling for handling increasingly complex mixtures. Such advances will help structural-omics methods extend to cellular-level models of structural biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据