期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 24, 期 2, 页码 1588-1598出版社
WILEY
DOI: 10.1111/jcmm.14848
关键词
epithelial-mesenchymal transition; interleukin-8; migration; ovarian cancer; Wnt; beta-catenin pathway
资金
- Foundation of Sichuan Provincial Science and Technology Program [2019YFH0147, 2019YFH0158]
- Chengdu technological innovation research and development project [2018-YF05-00195-SN]
- West China Second University Hospital Xinya fund [kx111]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYJC18016]
Interleukin-8 (IL-8), as an inflammatory chemokine, has been previously shown to contribute to tumorigenesis in several malignancies including the ovarian cancer. However, little is known about how IL-8 promotes the metastasis and invasion of ovarian cancers cells. In this study, we found that IL-8 and its receptors CXCR1 and CXCR2 were up-regulated in advanced ovarian serous cancer tissues. Furthermore, the level of IL-8 and its receptors CXCR1 and CXCR2 expression were associated with ovarian cancer stage, grade and lymph node metastasis. In vitro, IL-8 promoted ovarian cancer cell migration, initiated the epithelial-mesenchymal transition (EMT) program and activated Wnt/beta-catenin signalling. However, when treated with Reparixin (inhibitor of both IL-8 receptors CXCR1 and CXCR2), effect of both endogenous and exogenous IL-8 was reversed. Together, our results indicated that IL-8 triggered ovarian cancer cells migration partly through Wnt/beta-catenin pathway mediated EMT, and IL-8 may be an important molecule in the invasion and metastasis of ovarian cancer.
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