4.7 Editorial Material

FG-nucleoporins caught in the act of liquid-liquid phase separation

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JOURNAL OF CELL BIOLOGY
卷 219, 期 1, 页码 -

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ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201910211

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  1. Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) within the Emmy Noether program, SPP2191
  2. Munich Cluster for Systems Neurology [EXC2145]
  3. Fritz Thyssen Foundation
  4. Paul Ehrlich Foundation

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The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid-liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs.

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