期刊
JOURNAL OF CELL BIOLOGY
卷 219, 期 1, 页码 -出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201902014
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资金
- Simons Foundation [349247]
- NYSTAR
- National Institutes of Health, National Institute of General Medical Sciences [GM103310]
- National Institutes of Health [S10 RR029300-01]
- National Center for Advancing Translational Sciences grant (National Institutes of Health Clinical and Translational Science Award program) [UL1 TR001866]
- National Institute of General Medical Sciences of the National Institutes of Health [T32GM066699]
- Rockefeller University Women in Science Fellowship
Melanocytes are the neural crest-derived pigment-producing cells of the skin that possess dendrites. Yet little is known about how melanocyte dendrites receive and process information from neighboring cells. Here, using a co-culture system to interrogate the interaction between melanocyte dendrites and keratinocytes, we show that signals from neighboring keratinocytes trigger local compartmentalized Ca2+ transients within the melanocyte dendrites. The localized dendritic Ca2+ transients could be triggered by two keratinocyte-secreted factors, endothelin and acetylcholine, which acted via specific melanocyte receptors. Furthermore, compartmentalized Ca2+ transients were also generated on discrete dendritic spine-like structures on the melanocytes. These spines were also present in intact human skin. Our findings provide insights into how melanocyte dendrites communicate with neighboring cells and offer a new model system for studying compartmentalized signaling in dendritic structures.
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