期刊
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
卷 75, 期 4, 页码 284-291出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0000000000000803
关键词
ELABELA; APJ; apelin; cardiovascular system
资金
- National Natural Science Foundation of China [81720108003, 81800281]
- Shanghai Municipal Commission of Health and Family Planning [20184Y0062]
ELABELA (ELA), previously classified as a noncoding RNA, is a new endogenous peptidic ligand of apelin receptor (APJ/APLNR), a class A (rhodopsin-like) G protein-coupled receptor. It has been identified to play a crucial role in diverse biological processes, especially in the normal and pathological cardiovascular system. In comparison with APJ's first ligand apelin, ELA may play a key role at different time points or heart regions. In this review, we summarized the roles of the ELA-APJ signaling pathway in cardiovascular system development and diseases.
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