期刊
JOURNAL OF BIOSCIENCES
卷 45, 期 1, 页码 -出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-019-9978-z
关键词
Histone; nucleosome; heterochromatin; phase-separation; auto-inhibition
类别
资金
- NIH [R35GM127010]
The organization of chromatin into different types of compact versus open states provides a means to fine tune gene regulation. Recent studies have suggested a role for phase-separation in chromatin compaction, raising new possibilities for regulating chromatin compartments. This perspective discusses some specific molecular mechanisms that could leverage such phase-separation processes to control the functions and organization of chromatin.
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