期刊
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
卷 129, 期 5, 页码 638-645出版社
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2019.12.003
关键词
Anti-inflammatory; Anti-microbial; Cosmetics; Lactobacillus; Zanthoxylum schinifolium
资金
- BK21 plus program through the National Research Foundation (NRF) - Ministry of Education of Korea
- Korea Institute for Ministry of SMEs and Start-up (MSS) [R0006163]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [R0006163] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Fermented extracts have evolved to be a potential alternative to synthetic chemicals, owing to their anti-inflammatory and anti-bacterial properties. This study intends to assess the potential of fermented Zanthoxylum schinifolium extract for use in biomedical applications. Probiotic bacteria, Lactobacillus rhamnosus A6-5, were deployed as a seed culture for fermentation. The fermented extract showed greater tyrosinase inhibitory activity and reduced melanin production (58.3%) compared with the raw extract. Cytotoxicity assay inferred that 500 mg/mL is the ideal non-toxic concentration with maximum cell viability. In addition, DAPI staining did not show any damage to the chromatin structure of the cells. The anti-aging property of the fermented extract was confirmed by a decrease in IL-6 content. The fermented extract showed lower MIC (40 mg/mL) and MBC (60 mg/mL), indicating greater anti-bacterial activity than the raw extract. The results confirmed that the fermented Z. schinifolium extract has high biomedical properties compared with the raw extract and can be used as an ideal skin whitening agent. (C) 2019, The Society for Biotechnology, Japan. All rights reserved.
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